effects

 Question:A patient's nutritional intake and lab work reflect hypoalbuminemia.This is critical to prescribing because:Distribution of drugs to target tissue may be affected

The solubility of the drug will not match the site of absorption

There will be less free drug available to generate an effect

Drugs bound to albumin are readily excreted by the kidney

Question 2. Drugs that have a significant first-pass effect:

Must be given by the enteral (oral) route only

Bypass the hepatic circulation

Are rapidly metabolized by the liver and may have little if any desired action

Are converted by the liver to more active and fat-soluble forms

Question 3. An advantage of prescribing a sublingual medication is that the medication is:

Absorbed rapidly

Excreted rapidly

Metabolized minimally

Distributed equally

Question 4. Which one of the following statements about bioavailability is true?

Bioavailability issues are especially important for drugs with narrow therapeutic ranges or sustained release mechanisms.

All brands of a drug have the same bioavailability.

Drugs that are administered more than once a day have greater bioavailability than drugs given once daily.

Combining an active drug with an inert substance does not affect bioavailability.

Question 5. The route of excretion of a volatile drug will likely be:

The kidneys

The lungs

The bile and feces

The skin

Question 6. The time required for the amount of drug in the body to decrease by 50% is called:

Steady state

Half-life

Phase II metabolism

Reduced bioavailability time

Question 7. The elderly are at high risk of ADRs due to:

Having greater muscle mass than younger adults, leading to higher volume of distribution

The extensive studies that have been conducted on drug safety in this age group

The blood-brain barrier being less permeable, requiring higher doses to achieve therapeutic effect

Age-related decrease in renal function

Question 8. Patient education regarding prescribed medication includes:

Instructions written at the high school reading level Question 11.Nonadherence is especially common in drugs that treat asymptomatic conditions, such as hypertension. One way to reduce the likelihood of nonadherence to these drugs is to prescribe a drug that:

Has a short half-life so that missing one dose has limited effect

Requires several dosage titrations so that missed doses can be replaced with lower doses to keep costs down

Has a tolerability profile with less of the adverse effects that are considered "irritating," such as nausea and dizziness

Must be taken no more than twice a day

Question 12. A patient may develop neutropenia from using topical Silvadene for burns.Neutropenia is: